GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UVM | cis | rs9876781 | 1 | rs6442118 | chr3:48440047 | TREX1 | chr3:48501186-48509043:+ | -0.39 | -4.95 | 7.49E-6 | Longevity |
| UVM | cis | rs9876781 | 1 | rs6442119 | chr3:48440178 | TREX1 | chr3:48501186-48509043:+ | -0.39 | -4.83 | 1.13E-5 | Longevity |
| UVM | cis | rs9876781 | 1 | rs6442120 | chr3:48464503 | TREX1 | chr3:48501186-48509043:+ | -0.39 | -5.04 | 5.32E-6 | Longevity |
| UVM | cis | rs10461617 | 1 | rs6450408 | chr5:56098146 | C5orf35 | chr5:56205103-56213010:+ | 0.95 | 6.34 | 4.59E-8 | Type 2 diabetes |
| UVM | cis | rs10461617 | 1 | rs6450409 | chr5:56101399 | C5orf35 | chr5:56205103-56213010:+ | 0.95 | 6.34 | 4.59E-8 | Type 2 diabetes |
| UVM | cis | rs2028299 | 1 | rs6496609 | chr15:90379632 | AP3S2 | chr15:90373832-90456222:- | -0.73 | -6.11 | 1.06E-7 | Type 2 diabetes |
| UVM | cis | rs8078723 | 1 | rs6503530 | chr17:38161823 | GSDMA | chr17:38119226-38134019:+ | -0.87 | -7.55 | 4.73E-10 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| UVM | cis | rs9902453 | 1 | rs6505152 | chr17:28331466 | EFCAB5 | chr17:28256874-28435469:+ | -0.4 | -5.08 | 4.7E-6 | Coffee consumption (cups per day) |
| UVM | cis | rs9902453 | 1 | rs6505158 | chr17:28403348 | EFCAB5 | chr17:28256874-28435469:+ | -0.4 | -5.08 | 4.7E-6 | Coffee consumption (cups per day) |
| UVM | cis | rs1930961 | 1 | rs6519611 | chr22:25845855 | CRYBB2 | chr22:25615612-25627836:+ | 1.25 | 5.04 | 5.39E-6 | Bipolar disorder with mood-incongruent psychosis |
| UVM | cis | rs2273 | 1 | rs6532078 | chr4:76920809 | NAAA | chr4:76831809-76862166:- | -0.44 | -4.99 | 6.33E-6 | Longevity |
| UVM | cis | rs568617 | 1 | rs656980 | chr11:65656282 | SNX32 | chr11:65601410-65621170:+ | 0.63 | 5.51 | 9.72E-7 | Crohn's disease |
| UVM | cis | rs703842 | 1 | rs6581155 | chr12:58178162 | TSFM | chr12:58176536-58191367:+ | -0.58 | -5.23 | 2.71E-6 | Multiple sclerosis |
| UVM | cis | rs11190604 | 1 | rs6584379 | chr10:102224490 | SEC31B | chr10:102246403-102289636:- | -0.39 | -5.11 | 4.24E-6 | Palmitoleic acid (16:1n-7) plasma levels |
| UVM | cis | rs1411478 | 1 | rs6665134 | chr1:180949628 | STX6 | chr1:180913175-180992046:- | -0.58 | -5.69 | 5.07E-7 | Progressive supranuclear palsy |